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Patients with metabolic syndrome characterised by central obesity, insulin resistance, dyslipidaemia, and hypertensionoften exhibit elevated inflammatory markers
As a GLP-1 receptor agonist, it works by mimicking a natural hormone that targets the areas of the brain that regulate appetite and food intake
Discontinuing the medication often results in partial or full weight regain within 6 to 12 months, as the appetite-suppressing and metabolic effects of GLP-1s are no longer active
Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
Avoid harsh scrubs that may worsen inflammation
ghrelin is an orexigenic gut hormone that promotes appetite
