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Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow

H.GalvanD

Why Dosing Strategy Makes a Big Difference Both medications start at low doses to minimize side effects such as nausea or bloating

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However, as previously mentioned, genetic mutations are often inactive until an environmental stressor impacts the expression of the gene

Where It Acts The primary target cells are dermal fibroblasts (the cells responsible for producing collagen, elastin, and the extracellular matrix proteins that give skin its mechanical structure) and basal keratinocytes (the proliferating cell population at the bottom of the epidermis)