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(f-h) Analysis of mice from Fig

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These include yellow or green discharge from blisters, expanding areas of redness and warmth beyond the rash margins, fever, or red streaks extending from the rash site

First, it disrupts the process of melanin synthesis by inducing the release of high mobility group box 1 (HMGB1) protein, thus downregulating the melanin biosynthesis-related proteins: melanocyte-inducing transcription factor, tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, RAB27A and fascin actin-bundling protein 1 [17, 18]