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The FDA can take it or leave it," Tatem noted

One detail worth noting immediately

Starting from a therapeutic dose of 15 mg weekly, the schedule uses the same four-week intervals between each dose reduction

Signal Integration by JNK and P38 MAPK Pathways in Cancer Development

However, its high cost, reliance on specialized instrumentation, and limited scalability for large-scale studies pose challenges for routine use in DR biomarker discovery (41)