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176 In 1928, it was demonstrated by Zunc and LaBarre that the injection of secretin, which is extracted from the small intestinal mucosa, shows a hypoglycaemic effect that is mediated by the pancreas
For example, patients with large-artery atherosclerotic stroke and transient ischemic attack displayed obvious intestinal dysbacteriosis and reduced blood TMAO levels (Yin et al., 2015)
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No direct pharmacological link exists between GLP-1/GIP medicines and B12 deficiency, but concurrent metformin use (common in diabetes) is established to reduce B12 absorption
