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Glucocorticoid effects on somatomedins and somatomedin inhibitors

For patients with diabetes, monitoring for retinopathy is important, as rapid improvement in glycemic control with GLP-1 receptor agonists has been associated with temporary worsening of diabetic retinopathy in some cases

Notably, completed and ongoing studies such as NCT06475586, NCT06937060, NCT06588296, and NCT06864026 are investigating semaglutide in patients with PsO and comorbid metabolic conditions, or tirzepatide (in PsA settings), assessing dermatologic outcomes and inflammatory or metabolic markers (78, 79)

They studied patients in SELECT for about 4 years, giving half of them Wegovy and half of them placebo

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Under high glucose conditions, endothelial cells acquire the characteristics of fibroblasts, via endothelial-mesenchymal transition (EndMT)