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Tirzepatide is unique because it acts as a dual agonist for two important gut hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
This molecule features an extended, proline-rich C-terminal extension (sequence GAPPPS-NH 2 ) which is absent in GLP-1 itself
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B., & Flint, A
Medicine, 102 (41), e35521
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