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Gearhardt et al., 2009a, 2009b

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As research progresses, understanding the broader metabolic effects of these compounds could lead to comprehensive treatment strategies that target multiple aspects of metabolic syndrome

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Activation of TRL2 and TLR3 also causes inhibition and decreased expression of intestinal SERTs, resulting in extracellular accumulation of 5-HT and activation of 5-HT receptors, generating increased motility, nausea, and intestinal secretions