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Wegovy, Ozempic, and Rybelsus vary in purpose and outcomes, with Wegovy leading in average weight loss and Ozempic in blood sugar reduction

Tirzepatide is not recommended for people with a personal or family history of thyroid cancer or multiple endocrine neoplasia (MEN2), and it requires ongoing medical supervision

BMI 30+ with heart failure, uncontrolled high blood pressure, or chronic kidney disease

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In a clinical trial setting, your trial team will also have specific adverse event reporting procedures

For some, this shift is subtle