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If tirzepatide can reduce oral contraceptive absorption by 60%, it can affect oral HRT absorption as well
By this point, appetite suppression is well-established
It is generally recommended to take it either 30 minutes before a meal or two hours after eating
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The article says providers often use the two classes sequentially or together because they address different drivers of high blood sugar, and it describes combination therapy as common and effective when a single agent has not produced an adequate response
