pylori GGT accelerates the decrease of GSH levels in gastric epithelial cells, thereby exacerbating ROS production, leading to DNA damage and playing a key role in the emergence of chronic gastritis and gastric cancer (127)
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Therefore, RRM2 may play an anti-ferroptotic role in HCC cells
It also appeared linked to increased pituitary RNA and GH mRNA levels, suggesting a possible expansion of somatotroph cells
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A metastasis-prone signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics