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Both preclinical and clinical studies were included if they evaluated the effects of GLP-1 RAs on the major biological processes encompassed by the 12 hallmarks of aging, such as mitochondrial dysfunction, insulin resistance, dysbiosis, inflammaging, autophagy, proteostasis, and genomic stability

This powerful peptide increases IGF-1 levels with minimum effect on prolactin and cortisol

Seizures, Spreading Depolarizations and Peri-Tumoral Border Glutamate Release, Reuptake and Post-synaptic Action In the GBM peri-tumoral environment, there is a breakdown in glutamate homeostasis and subsequent pathological network signaling creates an environment favorable to seizures and SDs

Hydrolyzed collagen peptides are broken down into smaller units, making them easier for the body to absorb and use in rebuilding skin structure

Carr and Maggini, 2017)