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These groups included: a high-fat diet group (HF), a high-fat diet with Melanotan-II treatment group (HF + MT-II), a control diet group (C), and a control diet with Melanotan-II treatment group (C + MT-II)

The most common gastrointestinal side effects include nausea (affecting 1/10 patients), diarrhoea, constipation, abdominal pain, and vomiting

Increased cellular protein S -glutathionylation sensitized hepatocytes to TNF hepatotoxicity Increased cellular glutathionylated protein levels in response to GSSG accumulation prompted us to examine the effects of cellular protein S -glutathionylation on TNF-induced cell death

As also shown in related structural studies, the general base Glu 256 could further support the hydride transfer step of MSA-DH catalysis (Supplementary Figure S3 illustrates the spatial interplay of cofactor and substrate in the MSA-DH active site on the basis of the NAD(P) + and the MSA funnel