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Refrigerate consistently and do not leave at room temperature

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The principal mechanism of protraction resulting in the long half-life of semaglutide is albumin binding, which results in decreased renal clearance and protection from metabolic degradation

The shelf life after reconstitution is typically 28-30 days, though some sources cite up to 56 days for semaglutide specifically

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These include: Nausea Nausea is the most common side effect and is entirely dose-dependent