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Damaged dopaminergic neurons release matrix metalloproteinase 3, -synuclein, and neuromelanin that superactivated microglia, inducing reactive microgliosis, enhancing of the neurotoxicity-related mediators, such ROS (Figure 3)

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Single-cell RNA sequencing revealed that fibroblasts are the major source of extracellular matrix in DOX-induced myocardial fibrosis, with resting fibroblasts converting to matrifibrocytes and then myofibroblasts [94]

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Multiple articles and original research have concluded that oxidative stress plays a key role in COVID-19 and virally induced acute lung injuries [44, 74]