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Reference AOD-9604 Dosing Protocol In addition to its pill form, AOD-9604 is available for research as a lyophilized powder that should be reconstituted with bacteriostatic water and administered subcutaneously
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Citation11 The alternative route for transforming L-carnitine to TMA involves two sequential metabolic pathways contributed by two microbial gene clusters: caiTABCDE (L-carnitine BB) and gbuABCDEF (BB TMA), possessed by different gut microbes ( Citation14,Citation15 To determine which microbial gene cluster is crucial for TMAO production from L-carnitine metabolism by the gut microbiota, we performed OCCT and shotgun metagenome sequencing of fecal samples from subjects in three separate cohorts, comprising healthy adults and cardiovascular patients ( In the present study, three separate cohorts were recruited from different projects, each involving participants who underwent OCCT
Grant Number: 202401A134
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