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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
We chose the monothiol mutant PfGrx C32S/C88S for our studies to avoid side reactions that complicate the steady-state kinetics 33
To our knowledge, the innervation in the intestinal mucosa, including the ileum and colon, is predominantly vagal afferents, with minimal motor neurons present 66,67
In some cases, they can reverse the disease
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