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Our data showing blunted responses to exogenous CCK and downregulated hypothalamic Cckbr receptor in Bbs5 / mice support a model in which impaired CCK signaling contributes to hyperphagia

The Judicial Panel on Multidistrict Litigation (JPML) published an order on December 15, 2025, approving a request to create a dedicated MDL for blindness claims filed by patients who took Zepbound or other GLP-1s

It works by imitating the GLP-1 hormone, which is naturally released in the gut after eating

Taking too little will not lead to any positive effects on the ATP stores in the body

Additional evidence for an independent intrarenal RAS included observations that intrarenal ANG II contents markedly increased compared to circulating levels