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and for Boc-His(Boc)-OH.DCHA, the coupling was performed by a HOAt/HATU/TMP system

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Using diffusion enhanced resonance energy transfer (DERET 26 ), we observed rapid loss of cell surface SNAP-GLP-1Rs when exposed to exendin-4 and exendin-asp3, but much slower internalization with exendin-phe1 (Supplementary Fig