It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2
doi: 10.1093/schbul/sbx150
Codfish
Indeed, the association of doxorubicin with bioenergetic toxicity is well stated in the literature 32,33,34
NSAIDs can directly affect kidney function, while Trulicity-related kidney effects are primarily associated with dehydration from gastrointestinal side effects
This is different from intentionally skipping meals as a strategy, and the distinction matters clinically