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More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (30, 65, 67)

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This suggests that exacerbated inflammatory responses can persist even after the restoration of oxygen to the area of injury, as high levels of proinflammatory cytokines can re-stabilize HIF-1, perpetuating the transcriptional signaling cascade (Abdi Sarabi et al., 2022)

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PTGS2, prostaglandin-endoperoxide synthase 2