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Because a large number of comparisons were performed on the relative abundance data, main effect results from these analyses also underwent a BenjaminiHochberg false discovery rate (FDR) correction for multiple comparisons, and instances where a result was significant after this correction have been duly noted

The NAD connection: sustained NAD availability from NNMT inhibition has downstream effects that are not fully mapped across cell types

Zinc Sulfate: Plays a critical role in immune development and healing, accelerating recovery from colds, viruses, and wounds

Targeting Stubborn Fat Belly fat and visceral fat are often resistant to traditional diet and exercise

A mouse metabolises on a faster clock than a human, and a controlled diet in a cage is not a free-living human diet so even the week-numbers above should be read as the shape of a gradual response, not a promise that a human would see anything on the same calendar

Theoretical concerns are not proof of harm, but they identify areas off-target SAM effects, signalling-pathway impacts, and uncharacterised interactions that require study before any conclusion about human safety could be drawn