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Larger doses do not make up for missed days

Instruct patients to contact their healthcare provider if they have severe or persistent gastrointestinal symptoms [see Warnings and Precautions (5.7)]

Have you considered how temperature can affect your treatment

Moreover, high-fat feeding could significantly increase the body weight and the expression of MSTN in muscle of high-fat diet induced obesity susceptible mice models, but the expression of MSTN in muscle of high-fat diet induced obesity resistant mice does not change significantly (54)

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The trade-off is a slower timeline to full therapeutic effect