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The researchers hypothesized that weight loss with AOD9604 was driven by the beta-adrenergic pathway, more specifically the beta(3)-adrenergic receptors

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Microglia and macrophages also directly mediate tissue injury through the release of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-) and reactive mediators that contribute to oligodendrocyte and axonal damage (123)

Therefore, systematically examining these gaps in evidence is crucial for objectively assessing the reliability of this framework and guiding confirmatory studies

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