glp-1 and cardiovascular benefits Glucagon-like peptide 1 receptor agonists: mechanisms of action GLP-1 Agonists For Obesity In

In late-stage trials, people taking orforglipron lost an average of about 12% of their body weight over roughly 72 weeks , and head-to-head studies suggest it may outperform standard oral semaglutide tablets (Rybelsus) in both weight loss and blood sugar control

[1] Marketed under brand names including Ozempic, Wegovy, and Rybelsus, semaglutide works by mimicking the action of the naturally occurring hormone GLP-1

Agarwal A, et al

Here are a few common examples of how this can occur

Nakamura et al., 2025)

The study found that when patients experienced greater weight loss, they were less likely to discontinue the GLP-1 RA medications