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They are susceptible to degradation pathways that small molecules simply do not face, including deamidation, oxidation, aggregation, and hydrolysis
We explain why researchers include this ingredient in study formulas
Levothyroxine dosing is influenced by body weight, with typical maintenance doses ranging from 1.6-1.8 mcg/kg/day based on ideal or lean body weight (using actual body weight in obesity may lead to overreplacement)
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