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The homeostatic feeding is mainly orchestrated in the arcuate nucleus of the hypothalamus (Arc) by different types of neuron populations: the co-expressing Agouti-related protein (AgRP) and neuropeptide Y (NPY) neurons and the co-expressing pro-opiomelanocortin (POMC) and cocaine-amphetamine-related transcript (CART) neurons, with orexigenic and anorexigenic functions, respectively (Figure 1

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