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The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year
You will remain on a dose of anywhere between 5mg-15mg of Mounjaro for the long term
PHASE 2 OBESITY TRIAL Triple-Hormone Receptor Agonist Retatrutide for Obesity A Phase 2 Trial Published in the New England Journal of Medicine in 2023, this study reported substantial reductions in body weight across multiple dose groups and helped establish Retatrutide as one of the most closely followed compounds in obesity research
doi: 10.1016/j.neuron.2011.02.016, 79 KhanR.DotyR
In one retrospective study, 31% of a cohort of patients with haemochromatosis had concurrent hypertriglyceridaemia, and therapeutic phlebotomy more than halved triglycerides in affected individuals [83], suggesting a direct effect of iron overload on the development of hypertriglyceridaemia
