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Previously described cardiovascular effects of GLP-1 RAs are primarily indirect and include enhanced endothelial function and myocardial metabolism, natriuresis and anti-inflammatory and blood pressure-lowering effects

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Without this modification, GLP-1 would be cleared from the body within minutes, making therapeutic use impractical

These changes reflect the loss of GLP-1's effects on appetite centres in the brain and gastric emptying

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