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Elevated blood TMAO levels cause an imbalance in cholesterol homeostasis which leads to influenced macrophages, which in turn causes foam cell development and atherosclerotic plaques [68, 69, 71]

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Among these approaches, Kai Xin San (KXS), which consists of ginseng, hawthorn, polygala, and astragalus (316, 317), has been shown to regulate the HPA axis (318), and thus has potential as a treatment for depression

This is particularly beneficial for individuals engaged in strenuous training regimens