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These findings will contribute to the development of advanced targeted polypeptide nanocarrier platforms for potential therapeutic application in neuronal diseases
They pair well with lean protein, root vegetables, and grain bowls
Our finding of similar incidence of non-fatal cardiovascular outcomes with GLP1-RA compared to DPP4i is in line with the recently published FLOW study that randomized people with early to mid-stage CKD to semaglutide or placebo, which reported similar incidence of non-fatal myocardial infarction and non-fatal stroke across the semaglutide and placebo treated groups, despite a significantly reduced risk of major kidney disease events and all-cause death 44
Animal infusion models do show blunting with continuous exposure, which is expected for any GPCR agonist
doi: 10.1111/dom.14496
10.1186/s40779-018-0161-x 133 XiaoJ.LiX.GaoZ.MengF.LuJ.HouD.et al (2021)
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