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In a Phase II study reported in 2024 involving 168 patients with NASH, moderate to advanced fibrosis (F2F3), and NAS 4, a significantly greater proportion of patients in the denifanstat group achieved the primary endpoint compared with placebo, with statistically meaningful improvements in fibrosis as well

All participants were subjected to exercise counseling and calorie restriction and randomly assigned either a placebo or Wegovy, which is prescribed for adult weight loss

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