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It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)
Adv Pharmacol Pharm Sci 2023(1):7867497 Srivastava N, Bagchi G (2006) Influence of micronutrient availability on biomass production in Cineraria maritima
Pairing MOTS-c with structured exercise, creatine, and mitochondrial support compounds addresses mitochondrial health through complementary and reinforcing mechanisms
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KPV On 23 July 2026, PCAC voted to recommend adding KPV to the 503A Bulks List, in opposition to the FDA staff review, which had recommended against listing
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