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Both heavy alcohol use and tirzepatide are independently associated with an increased risk of pancreatitis - a serious inflammation of the pancreas

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These can include feeling emotionally flat or numb, reduced interest in hobbies, socializing, or activities that used to bring joy, a sense that life has become "meh," and less emotional reactivity both positive and negative

Vitamin B12 Though not a direct effect of fasting, low Vitamin B12 levels can occur with reduced overall food intake or long-term use of certain medications (including metformin, which is sometimes co-prescribed with semaglutide)

Additionally, Semaglutide slows gastric emptying