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As research evolves, clinical guidelines may eventually incorporate cognitive outcomes into diabetes treatment algorithms, but current practice should remain grounded in established evidence and FDA-approved indications

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Where does the available human evidence sit on the study design hierarchy: case report (low grade), retrospective series, or controlled trial (higher grade)

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Trimethylamine N-oxide, Mediterranean diet, and nutrition in healthy, normal-weight adults: Also a matter of sex

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Third, the development of novel targeted therapies is still in the preclinical stage, and there is an urgent need for well-designed clinical trials to evaluate their safety and efficacy in humans

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Giustina (Universit degli Studi, Brescia), Prof

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