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If you are using multi-dose vials and accuracy is critical, low dead-space syringes can recover 5 to 10% more product from each vial

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Oct-Dec 2009;51(4):217-24

Discard both needles and the syringe after use

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5.10 Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use Concomitant administration of topiramate and valproate has been associated with hyperammonemia with or without encephalopathy in patients who have tolerated either drug alone