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We further demonstrate that the suppression of ferroptosis by FSP1 is mediated by ubiquinone (also known as coenzyme Q10 (CoQ10)): the reduced form, ubiquinol, traps lipid peroxyl radicals that mediate lipid peroxidation, whereas FSP1 catalyses the regeneration of CoQ10 using NAD(P)H

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Hernndez-Saavedra D, Hinkley JM, Baer LA, Pinckard KM, Vidal P, Nirengi S, et al

To address this issue, tamoxifen (Tam)-inducible cartilage-specific IGF-IR KO ( TamCar IGF-I R / ) mice were studied (33,34)

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