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Some people on Ozempic will find the medication is so effective at lowering appetite that they struggle to eat enough calories to support their bodys primary functions, like digestion
Constipationdefined as having fewer than three bowel movements per week, hard or dry stools, or difficulty or pain with passage of stoolis a recognized adverse effect of GLP-1 receptor agonists, though it occurs less frequently than nausea or diarrhea
People taking it for weight loss have lower appetites, and also contend with side effects like nausea, vomiting, diarrhea, and constipation
But the mechanisms suggest potential for enhanced results when MOTS-c supplementation accompanies a training program
Understanding these multifaceted interactions is essential for developing targeted interventions to prevent or mitigate the adverse effects of obesity and NAFLD on bone health
Nature 638 , 411417 (2025)
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