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Any over-activity or inhibition of these systems may lead to lesions in different organs
The enzyme transfers a 2C ketol group from xylulose-5-phosphate to ribose-5-phosphate, an aldose
Colonic motility decreases
Plasma AMG 133 exposure as assessed by maximum observed concentration ( C max ) and area under the concentrationtime curve (AUC) from time 0 to the time of the last measured concentration (AUC last ) increases with increasing dose
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Guan et al., 1997
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