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When your overall food volume drops by 30% to 50% on semaglutide, your water intake from food drops proportionally unless you compensate by drinking more

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"Both magnesium and creatine can take weeks to have beneficial effects because the body must reach certain levels, which takes time, to have an increased effect on health and physical activity," Kari Franson, PharmD, PhD, professor of clinical pharmacy and director of the sports pharmacy program at USC Mann, told Verywell in an email

Thus, patients taking the agents associated with the greatest weight loss, tirzepatide and semaglutide, have the highest incidence of developing both hypocalcemia and hypercalcemia