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Overall, current epidemiologic evidence shows that GLP-1RAs consistently induce fat loss accompanied by proportional lean tissue reduction (Table 1)

Comparative Mechanisms with Other Agents Compared with metformin, which improves insulin sensitivity primarily through hepatic and muscular pathways, GLP-1 RAs act centrally and peripherally to influence appetite, glucose metabolism, and systemic inflammation

Whilst these procedures typically produce substantial initial weight loss, weight regain is a recognised clinical challenge that affects a significant proportion of patients in the years following surgery

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