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Stress management : Techniques like meditation, yoga, and deep breathing can reduce stress, which can be a barrier to weight loss

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In this review, we synthesize clinical and preclinical evidence demonstrating that KP dysregulation constitutes a convergent mechanism linking stress, inflammation, excitotoxicity, and oxidative stress in MDD, and critically evaluate its potential as a source of biomarkers and therapeutic targets (see Fig

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This does not diminish the therapeutic value of GLP-1 medications but instead underscores the importance of viewing weight loss through a broader physiological lens that accounts for body composition and long-term cardiometabolic health