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A molecule can be essential inside the body without an infusion of that molecule being proven to improve symptoms in a healthy person

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Hyperglycaemia differentially affects energy metabolism across kidney cell types, for example impeding glycolysis in glomerular epithelial cells (where glucose is the preferred energy substrate) while enhancing glycolysis in proximal tubular epithelial cells (which typically rely on fatty acid oxidation) [11]

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Female-specific outcomes are embedded in the clinical data reviewed throughout this guide