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Menstrual irregularity, PCOS, premature ovarian insufficiency, difficulty conceiving and infertility, and pregnancy loss have been linked to sleep disturbances and disorders

Therefore, we conducted a systematic review to examine whether OA progression in patients with type 2 diabetes was affected by metformin treatment The systematic review revealed that type 2 diabetes patients treated with metformin showed a lower incidence of knee arthroplasty (Fig

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