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Receptor-specific differences include D9R7.35b and D15R299 salt bridges shared by GLP-1R and GIPR (but absent in GCGR, which has Q374 in ECL3 and I194 at position 2.67b), and GCGR-specific -stacking between Phe6 and Y138 1.36b

Notably, post-mortem studies revealed reduced activity of respiratory chain complexes in a group of ASD children, suggesting that abnormalities, especially in the frontal, temporal and cerebellar areas (Tang et al., 2013), may cause mitochondrial impairment and contribute to the appearance of the first symptoms (Siddiqui et al., 2016)

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doi: 10.1016/j.diabres.2019.05.001 51 PerkovicV.De ZeeuwD.MahaffeyK