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10 Endogenous GLP-1 causes peripheral food intake effects, including delay gastric emptying as well as reduction in gastrointestinal secretions and gastric mobility
CJC-1295 has been marketed with and without drug affinity complex (DAC) technology, which extends its half-life and resultant therapeutic window as follows [2]: CJC-1295 No DAC: CJC-1295 No DAC contains only straight CJC-1295 with a D-Ala at the 2-position, a Gln at the 8-position (to reduce asparagine rearrangement), an Ala at position 15 (to enhance bioactivity), and a Leu at position 27 (to prevent methionine oxidation)
On the other hand, there have been some case reports of drug-induced lupus associated with GLP1-RA use, in particular with semaglutide, so further study is warranted15
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Lymphocyte-derived ACh regulates local innate but not adaptive immunity
The first peptide polyagonist that was officially approved for T2DM and obesity was tirzepatide (LY3298176), a dual GLP-1/GIP receptor agonist which is currently under investigation in RCTs for obesity and NAFLD [7]
