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"Physicians should be concerned about the increased risk of gallbladder or biliary disease associated with GLP-1 RA use, especially at the higher doses recommended for weight loss," the authors write

When administered at doses of 0, 0.1, 0.25, and 0.5 ug/mL, growth hormone receptor expression was increased in a dose-dependent manner

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However, given the close association between obesity and OSA, as well as the effectiveness of other forms of weight loss in combating OSA, incretin-based therapies hold promise as a therapeutic option for the management of obesity-related OSA

In experimental settings, it is explored for its influence on circadian rhythms, cortisol modulation, and central nervous system balance

doi: 10.2337/dc13-2817 80 Debray-SachsMCarnaudCBoitardCCohenHGresserIBedossaPet al