In rare cases, B12 can cause diarrhea, peripheral vascular thrombosis, itching, transitory exanthema, urticaria, feelings of swelling of the whole body
For milder vitamin B12 deficiency, where circumstances make delay difficult, there may be room for discussion of enhanced perioperative supplementation (such as intramuscular B12 close to surgery and continued through recovery)
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When treated with vitamin B12 (intramuscular injection), vitamin B12 levels normalized, and moreover, visual functioning improved in all 3 children