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A number of macronutrients have also been shown to have an impact on gastric motility: high-protein meals can shorten the initial latency of gastric emptying, while fibre, particularly indigestible components, can significantly slow it [4, 5]

However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies

Jain SK et al

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For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg

Sip this one slowly over 20-30 minutes