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Chemical Structure and Biosynthesis Although dopaminergic neurons represent less than 1% of cell subtypes in the brain, dopamine embodies approximately 80% of catecholamines in the CNS, though this figure is an estimate and may vary depending on measurement methods 1 Dopamine is a catecholamine that is primarily synthesized by dopaminergic neurons located in the substantia nigra and ventral tegmental area (VTA) of the brain, where this chemical messenger primarily functions as a neurotransmitter

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doi:10.1056/NEJMoa1616011 26Gerstein HC, Colhoun HM, Dagenais GR, et al

Starting the new drug at a dose "equivalent" to your old drug instead of at the starting dose dramatically increases side effect risk

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